Journal
CIRCULATION RESEARCH
Volume 126, Issue 4, Pages 533-551Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.119.315889
Keywords
aging; epigenetics; exercise; heart failure; senescence
Funding
- NIH [AG061034, HL122987, HL135886, K08HL140200, K76AG064328]
- AHA [16SFRN31720000, 16FTF29630016, 14FTF20440012]
- Fred and Ines Yeatts Fund for Innovative Research
- Foundation for Anesthesia Education and Research (FAER)
- Sarnoff Cardiovascular Research Foundation Fellowship
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During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming increasingly urgent as the elderly population continues to grow. Our understanding of cardiac aging, and aging in general, is limited. However, recent studies of age-related decline and its prevention through interventions like exercise have revealed novel pathological and cardioprotective pathways. In this review, we summarize recent findings concerning the molecular mechanisms of age-related heart failure and highlight exercise as a valuable experimental platform for the discovery of much-needed novel therapeutic targets in this chronic disease.
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