Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 38, Issue 4, Pages 420-421Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201900490
Keywords
m(6)A; Epitranscriptomics; Small-molecule intervention; Drug discovery; RNA
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The m(6)A-RNA modification is a dynamic and reversible process, which has emerged as a new RNA code for the regulation of gene expression. The functional network of methyltransferases (writers), demethylases (erasers), and binding proteins (readers) modulate the level of m(6)A modification. Dysfunction of RNA methylation has been associated with various fundamental biological processes and human diseases. Herein, we briefly introduce an understanding-enabled manipulation on m(6)A-RNA modification with an emphasis on the use of small-molecule intervention.
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