Ir/Phase-Transfer-Catalysis Cooperatively Catalyzed Asymmetric Cascade Allylation/2-aza-Cope Rearrangement: An Efficient Route to Homoallylic Amines from Aldimine Esters

The Summary of main observation and conclusion Herein, we developed an Ir/phase-transfer-catalysis cooperatively catalyzed asymmetric cascade allylation/2-aza-Cope rearrangement of aldimine esters to prepare synthetically important homoallylic amines in good yields with excellent enantioselectivities. Compared with the bimetallic catalytic system to realize this transformation, the current cooperative Ir/tetrabutyl ammonium bromide catalytic system provides an alternative but more practical approach, which not only simplify the manipulation process but also increase the cost efficiency.