Journal
CHEMSUSCHEM
Volume 13, Issue 11, Pages 2828-2858Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.202000137
Keywords
asymmetric catalysis; cleaner synthesis technology; green chemistry; organocatalysis; sustainable chemistry
Funding
- Slovak Research and Development Agency [APVV-17-0239]
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Asymmetric organocatalysis is becoming one of the main tools for the synthesis of chiral compounds that are needed as medicines, crop protection agents, and other bioactive molecules. It can be effectively combined with various green chemistry methodologies. Intensification techniques, such as ball milling, flow, high pressure, or light, bring not only higher yields, faster reactions, and easier product isolation, but also new reactivities. More sustainable reaction media, such as ionic liquids, deep eutectic solvents, green solvent alternatives, and water, also considerably enhance the sustainability profile of many organocatalytic reactions.
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