Journal
CHEMPHYSCHEM
Volume 21, Issue 7, Pages 667-672Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.201901056
Keywords
coherent emission; NMR spectroscopy; para-hydrogen induced polarization; magnetic properties; RASER
Funding
- Emmy Noether Program metabolic and molecular MR [HO 4604/2-2]
- research training circle materials for brain [GRK 2154/1-2019]
- DFG-RFBR [HO 4604/3-1, 19-53-12013]
- German Federal Ministry of Education and Research (BMBF) [01ZX1915C, PMI 1267]
- Kiel University
- European Regional Development Fund (ERDF)
- Zukunftsprogramm Wirtschaft of Schleswig-Holstein [122-09-053]
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Nuclear Magnetic Resonance (NMR) is an intriguing quantum-mechanical effect that is used for routine medical diagnostics and chemical analysis alike. Numerous advancements have contributed to the success of the technique, including hyperpolarized contrast agents that enable real-time imaging of metabolism in vivo. Herein, we report the finding of an NMR radio amplification by stimulated emission of radiation (RASER), which continuously emits H-1 NMR signal for more than 10 min. Using parahydrogen induced hyperpolarization (PHIP) with 50 % para-hydrogen, we demonstrated the effect at 600 MHz but expect that it is functional across a wide range of frequencies, e.g. 10(1)-10(3) MHz. PHIP-RASER occurs spontaneously or can be triggered with a standard NMR excitation. Full chemical shift resolution was maintained, and a linewidth of 0.6 ppb was achieved. The effect was reproduced by simulations using a weakly coupled, two spin-1/2 system. All devices used were standard issue, such that the effect can be reproduced by any NMR lab worldwide with access to liquid nitrogen for producing parahydrogen.
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