Journal
CHEMMEDCHEM
Volume 15, Issue 4, Pages 349-353Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201900591
Keywords
drug resistance; cancer; metal complexes; cellular imaging; OLEDs
Categories
Funding
- SACO AEI Polymers UK
- Frankfurter Stiftung fur krebskranke Kinder
- Hilfe fur krebskranke Kinder Frankfurt e.V.
Ask authors/readers for more resources
Thiourea and guanidine units are found in nature, medicine, and materials. Their continued exploration in applications as diverse as cancer therapy, sensors, and electronics means that their toxicity is an important consideration. Iridium complexes present new opportunities for drug development and imaging in terms of structure and photoactivity. We have systematically synthesised a set of thiourea and guanidine compounds and iridium complexes thereof, and elucidated structure-activity relationships for cellular toxicity in three ovarian cancer cell lines and their cisplatin-resistant sub-lines. We have been able to use the intrinsic luminescence of iridium complexes to visualise the effect of both structure alteration and cellular resistance mechanisms. These findings provide starting points for the development of new drugs and consideration of safety issues for novel thiourea-, guanidine-, and iridium-based materials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available