Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 15, Issue 1, Pages 148-155Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201901394
Keywords
Ag@TiO2 nanoprisms; melanoma therapy; nanomedicine; photothermal therapy
Categories
Funding
- Beijing Municipal High Level Innovative Team Building Program [IDHT20180504]
- Beijing Outstanding Young Scientists Program [BJJWZYJH01201910005017]
- National Natural Science Foundation of China [21805004, 21671011, 21872001, 51801006]
- Beijing Natural Science Foundation [KZ201710005002, 2192005]
- China Postdoctoral Science Foundation [2018M641133]
- Beijing Postdoctoral Research Foundation [2018-ZZ-021]
- Chaoyang District Postdoctoral Research Foundation [2018-ZZ-026]
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Melanoma is a primary reason of death from skin cancer and associated with high lethality. Photothermal therapy (PTT) has been developed into a powerful cancer treatment technique in recent years. Here, we created a low-cost and high-performance PTT agent, Ag@TiO2 NPs, which possesses a high photothermal conversion efficiency of approximate to 65 % and strong near-infrared (NIR) absorption about 808 nm. Ag NPs were synthesized using a two-step method and coated with TiO2 to obtain Ag@TiO2 NPs by a facile sol-gel method. Because of the oxide, Ag@TiO2 NPs exhibit remarkable high photothermal conversion efficiencies and biocompatibility in vivo and in vitro. Cytotoxicity and therapeutic efficiency of photothermal cytotoxicity of Ag@TiO2 NPs were tested in B16-F10 cells and C57BL/6J mice. Under light irradiation, the elevated temperature causes cell death in Ag NPs-treated (100 mu g mL(-1)) cells in vitro (both p<0.01). In the case of subcutaneous melanoma tumor model, Ag@TiO2 NPs (100 mu g mL(-1)) were injected into the tumor and irradiated with a 808 nm laser of 2 W cm(-2) for 1 minute. As a consequence, the tumor volume gradually decreased by NIR laser irradiation with only a single treatment. The results demonstrate that Ag@TiO2 NPs are biocompatible and an attractive photothermal agent for cutaneous melanoma by local delivery.
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