Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 15, Issue 7, Pages 1175-1179Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202000059
Keywords
Silver; alpha; alpha-Difluoroarylacetic acid; Allylation; Water; radical keyword 5
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Funding
- Education Department of Shaanxi Province [19JK0148] Funding Source: Medline
- Shaanxi University of Science and Technology [2016BJ-67] Funding Source: Medline
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A practical silver-catalyzed decarboxylative allylation of alpha,alpha-difluoroarylacetic acids with allyl sulfones is described, which provides a variety of beta,beta-difluorinated alkenes in good yields. Notably, the reaction proceeds smoothly in water with good functional group tolerance. The practicality and synthetic value of this process was demonstrated by scaled-up experiment and elaboration of the products via reduction or Heck reaction. Primary mechanism investigations suggest that a radical process might be involved.
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