Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 7, Pages 1668-1675Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201904704
Keywords
click reactions; drug delivery; multimodal cancer treatment; nanoplatforms; Ru-II polypyridyl complexes
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Funding
- National Nature Science Foundation of China [21877084, 21671150, 81171646, 31170776, 21472139]
- Science and Technology Commission of Shanghai Municipality [14DZ2261100]
- Fundamental Research Funds for the Central Universities [kx0150720173382]
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Despite drug delivery nanoplatforms receiving extensive attention, development of a simple, effective, and multifunctional theranostics nanoplatform still remains a challenge. Herein, a versatile nanoplatform based on a zirconium framework (UiO-66-N-3) was synthesized, which demonstrated a combined photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy (CT) for cancer treatment. A Ru-II polypyridyl alkyne complex (Ra) as a photosensitizer was modified into a nanoplatform by click reactions for the first time. When exposed to suitable light irradiation, the as-prepared multifunctional nanoplatform (UiO-Ra-DOX-CuS) not only demonstrated efficient O-1(2) generation, but also exhibited excellent photothermal conversion ability. In particular, the nanotherapeutic agent presented a dual-stimuli response; either acidic environment or NIR laser irradiation would trigger the drug release. The synergetic efficacy of UiO-Ra-DOX-CuS combined PDT, PTT, and CT, which was evaluated by cell experiments. Moreover, the design could promote the development of Ru-II polypyridyl alkyne complexes based multifunctional nanoparticles and multimodal cancer treatment.
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