Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 27, Pages 6064-6069Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202000515
Keywords
carbon dioxide; carboxylation; C-H activation; green solvent; late-stage functionalization
Categories
Funding
- NordForsk [85378]
- Tromso Research Foundation [TFS2016KHH]
Ask authors/readers for more resources
A formal C-H carboxylation of unactivated arenes using CO2 in green solvents is described. The present strategy combines a sterically controlled Ir-catalyzed C-H borylation followed by a Cu-catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C-H carboxylation of 1,3-disubstituted and 1,2,3-trisubstituted benzenes, 1,2- or 1,4-symmetrically substituted benzenes, fluorinated benzenes and different heterocycles. The developed methodology was applied to the late-stage C-H carboxylation of commercial drugs and ligands.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available