Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 9, Pages 1906-1921Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201903961
Keywords
allylic compounds; cyclization; nucleophilic substitution; synthetic methods; total synthesis
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Funding
- Tamaki Foundation
- Chugai Pharmaceuticals
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Metal-catalyzed allylic alkylation reactions between dual nucleophiles and dual electrophiles represent a powerful set of methods for the synthesis of small-, medium-, and even large-sized rings. Using this strategy, a handful of simple allylic diol derivatives can be transformed into a broad array of complex carbo- and heterocycles of varying ring sizes in just a single step. Because of their ability to rapidly generate complexity, annulative allylic alkylation reactions between dual nucleophiles and dual electrophiles have been extensively employed in the total synthesis of both natural products and pharmaceutical compounds.
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