Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 33, Pages 7416-7424Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202000335
Keywords
cancer stem cells; chemoselective oxidation; reactive oxygen species (ROS); salinomycin; stereoselective reductive amination
Categories
Funding
- CNRS
- INSERM
- Institut Curie
- European Research Council [647973]
- Fondation Charles Defforey-Institut de France
- Labellisation Ligue Contre le Cancer
- Region Ile de France
- PSL Research University
- European Research Council (ERC) [647973] Funding Source: European Research Council (ERC)
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Salinomycin (1) exhibits a large spectrum of biological activities including the capacity to selectively eradicate cancer stem cells (CSC), making it and its derivatives promising candidates for the development of drug leads against CSC. It has been previously shown that salinomycin and its C20-propargylamine derivative (Ironomycin (2)) accumulate in lysosomes and sequester iron in this organelle. Herein, a library of salinomycin derivatives is reported, including products of C20-amination, C1-esterification, C9-oxidation, and C28-dehydration. The biological activity of these compounds is evaluated against transformed human mammary epithelial HMLER CD24(low)/CD44(high) cells, a well-established model of breast CSC, and HMLER CD24(high)/CD44(low) cells deprived of CSC properties. Unlike other structural alterations, derivative 4, which displays a cyclopropylamine at position C20, showed a strikingly low IC50 value of 23 nm against HMLER CD24(low)/CD44(high) cells. This study provides highly selective molecules to target the CSC niche, a potential interesting advance for drug development to prevent cancer resistance.
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