Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 56, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1007/s10600-020-02942-2
Keywords
arylbenzofuran lignans; Arctium lappa; anti-MRSA activity
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Funding
- National Natural Science Foundation of China [21562044]
- Joint Foundation of Yunnan Province-Kunming Medical University [2017FE468(-186)]
- Research Foundation of China Tobacco Yunnan Industrial Co., Ltd. [2019SC04]
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Two new (1 and 2) and two known arylbenzofuran lignans (3 and 4) were isolated from the seeds of Arctium lappa. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-4 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compound 3 showed good inhibition with IZD of 13.5 +/- 1.5 mm), and compounds 1, 2, and 4 showed weak inhibition with IZD of 9.6 +/- 1.0, 11.6 +/- 1.2, and 10.8 +/- 1.2 mm, respectively. Compounds 1-4 were also tested for the antioxidant activity, and they show good antioxidant activity with an IC50 values of 4.38, 4.22, 3.96, and 4.15 mu g/mL, respectively.
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