Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 226, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2019.104836
Keywords
Extracellular vesicles; Exosomes; Clinical applications
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Funding
- Cellular and Molecular Research Center of Shahrekord University of Medical Sciences
- Kurdistan University of Medical Sciences
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Exosomes are cup-shaped structures, made of two lipid layers. Their size is in the range of 30-150 nm. Exosomes are excreted to the extracellular space and function in local and systemic cellular communication. Based on their primary origins, they can contain substantial amounts of RNA, protein, and miRNA; the horizontal transfer of these contents significantly determines the exosome's biological effects. The endosomal origins of exosomes can be deduced based on their surface protein markers. The use of exosomes as a diagnostic biomarker and therapeutic tool, has numerous advantages because they do not pose risks such as aneuploidy and transplant rejection. This - overview highlights the recent findings in exosome development and current knowledge in exosome-based therapies.
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