Journal
CHEMISTRY & BIODIVERSITY
Volume 17, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202000035
Keywords
Schisandra chinensis; lignans; terpenoids; cytotoxicity; biological activity
Funding
- National Natural Science Foundation of China (NSFC) [81473325]
- China Postdoctoral Science Foundation [2018M631978]
- Excellent Youth Project of Heilongjiang Natural Science Foundation [YQ2019H029]
- Heilongjiang Postdoctoral Science Foundation [LBH-Z18245]
- Heilongjiang University of Chinese Medicine Founds [2018pt01, 2018bs03]
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Fifteen constituents, including one new lignan (schisandroside E) and one new terpenoid (schisandenoid A) as well as nine known lignans and four known terpenoids, were isolated from Schisandra chinensis leaves. The structures of schisandroside E and schisandenoid A were established by entirely meticulous spectroscopic analysis (NMR, MS, CD, IR and UV). All compounds were tested for cytotoxicity against MGC-803, Caco-2 and Ishikawa cell lines. Some compounds showed strong cytotoxicity against these three cancer cell lines with IC(50)m.
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