Journal
CHEMISTRY & BIODIVERSITY
Volume 17, Issue 2, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201900656
Keywords
Cunila angustifolia; pulegone; menthol; terpene; essential oil
Funding
- CAPES
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The Cunila angustifolia essential oil was obtained from fresh leaves by hydrodistillation and analyzed by GC-FID and GC-MS to determine its chemical composition. The essential oil presented pulegone (29.5 %) and isomenthol (27.0 %) as major components, and other compounds such as menthone (8.6 %), neomenthol (7.2 %), menthyl acetate (2.5 %) and caryophyllene oxide (2.0 %) were identified. The cytotoxic activity of the essential oil was evaluated by MTS assay, with the human cancer cell lines of the lung (A549), breast (MCF-7) and skin melanoma (SK-Mel-28). The assay showed the highest selectivity, to MCF-7 cell lines, with IC50 equal to 34.0 mu g mL(-1), low selectivity for SK-Mel-28 cell lines, with IC50 equal to 279.9 mu g mL(-1), and no mortality to A549 cell lines.
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