Journal
CHEMISTRY & BIODIVERSITY
Volume 17, Issue 2, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201900499
Keywords
Garcinia; mangostin; mangiferin; gambogic acid; 5; 6-dimethylxanthone-4-acetic acid
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- Universidade do Vale do Itajai (UNIVALI)
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Xanthones are a class of heterocyclic natural products that have been widely studied for their pharmacological potential. In fact, they have been serving as scaffolds for the design of derivatives focusing on drug development. One of the main study targets of xanthones is their anticancer activity. Several compounds belonging to this class have already demonstrated cytotoxic and antitumor effects, making it a promising group for further exploration. This review therefore focuses on recently published studies, emphasizing their natural and synthetic sources and describing the main mechanisms of action responsible for the anticancer effect of promising xanthones.
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