Journal
CHEMISTRY & BIODIVERSITY
Volume 17, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201900744
Keywords
azaphilone; Chaetomium globosum; Polygonatum sibiricum; structure identification; cytotoxicity
Funding
- Key Project at Central Government Level: The Ability Establishment of Sustainable Use for Valuable Chinese Medicine resources [2060302]
- Fundamental Research Funds for the Central Universities
- National Science and Technology Fundamental Resources Investigation Program of China [2018FY100800]
- National Natural Science Foundation of China [21702187, 31870332, 31860583, 31470414]
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A new azaphilone, chaephilone E, eight azaphilone derivatives, and three chaetoglobosins were isolated from endophytic fungi Chaetomium globosum. The structures of the compounds were elucidated by 1D and 2D NMR as well as HR-ESI-MS data, and the absolute configuration of chaephilone E was established on the basis of electronic circular dichroism and NOESY spectrum. The activity of chaephilone E was evaluated via the cytotoxic assay (human hepatoma cell lines HepG-2) and brine shrimp (Artemia salina) bioassay.
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