Journal
CHANNELS
Volume 14, Issue 1, Pages 79-86Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336950.2020.1734266
Keywords
TRPM8; PIP2; phosphoinositides; GPCR; G-alpha-q
Categories
Funding
- National Institute of General Medical Sciences [GM131048]
- National Institute of Neurological Disorders and Stroke [NS055159]
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The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P-2]. This review discusses recent findings on the role of PI(4,5)P-2 and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P-2 in Ca2+ dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.
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