4.7 Article

Tuning biodegradability and biocompatibility of mesoporous silica nanoparticles by doping strontium

Journal

CERAMICS INTERNATIONAL
Volume 46, Issue 8, Pages 11762-11769

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2020.01.210

Keywords

Mesoporous silica nanoparticle; Strontium; Doping; Biodegradability; Biocompatibility; Ions release

Funding

  1. National Natural Science Foundation of China [31670969, 31571030, 51302089, 31800791]
  2. Natural Science Foundation of Guangdong Province [2018030310062]
  3. China Postdoctoral Science Foundation [2016M602601, 2018T110926]

Ask authors/readers for more resources

Mesoporous silica nanoparticle (MSN), one of the most widely used nanomaterials, is of poor biodegradability in vivo due to its highly stable Si-O-Si structure. Here, the structural stability of Si-O-Si was regulated by doping strontium ion. Sr-doped MSNs (Sr-MSNs) were synthesized by a cetyltrimethylammonium-bromide-mediated template method and their phase, morphology, structure, physicochemical properties, in vitro degradability and cytocompatibility were investigated. Results indicated that Sr2+ was successfully incorporated into MSN with the collapse of the ordered mesoporous structure. Sr-doping significantly improved the specific surface area, in vitro degradability and cytocompatibility of MSN in a Sr-content-dependent manner. Particularly, excessive Sr-doping gave rise to generating impure strontium silicate which converted into disordered amorphous silica during degradation and hindered the biodegradable behaviors of MSN. Hence, the synthetic Sr-MSNs with excellent surface nature, biodegradability and biocompatibility were supposed to be applied as potential carriers for the controllable release of drugs and ions in numerous clinical applications.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available