Journal
CELLULAR SIGNALLING
Volume 65, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2019.109427
Keywords
CD44; Hyaluronan; Receptor tyrosine kinase; Viral infection; Proteolytic cleavage; EMT
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Funding
- Swedish Cancer Society [2015-0778]
- Swedish Research Council [2015-02757]
- Ludwig Institute for Cancer Research, Uppsala University
- Ministry of Science and Technology, Taiwan [106-2314-B-037-088-, 1062915-1-037-501-]
- Kaohsiung Medical University Hospital [KMUH103-3T05]
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Hyaluronan and its major receptor CD44 are ubiquitously distributed. They have important structural as well as signaling roles, regulating tissue homeostasis, and their expression levels are tightly regulated. In addition to signaling initiated by the interaction of the intracellular domain of CD44 with cytoplasmic signaling molecules, CD44 has important roles as a co-receptor for different types of receptors of growth factors and cytokines. Dysregulation of hyaluronan-CD44 interactions is seen in diseases, such as inflammation and cancer. In the present communication, we discuss the mechanism of hyaluronan-induced signaling via CD44, as well as the involvement of hyaluronan-engaged CD44 in malignancies and in viral infections.
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