Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 77, Issue 14, Pages 2771-2794Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-020-03454-6
Keywords
Regenerative potential; Integration of MSCs; Immunomodulation; Soluble factors; Cell-cell contact; Mitochondrial transfer; Extracellular vesicles
Categories
Ask authors/readers for more resources
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of various diseases. The therapeutic potential of MSCs is attributed to complex cellular and molecular mechanisms of action including differentiation into multiple cell lineages and regulation of immune responses via immunomodulation. The plasticity of MSCs in immunomodulation allow these cells to exert different immune effects depending on different diseases. Understanding the biology of MSCs and their role in treatment is critical to determine their potential for various therapeutic applications and for the development of MSC-based regenerative medicine. This review summarizes the recent progress of particular mechanisms underlying the tissue regenerative properties and immunomodulatory effects of MSCs. We focused on discussing the functional roles of paracrine activities, direct cell-cell contact, mitochondrial transfer, and extracellular vesicles related to MSC-mediated effects on immune cell responses, cell survival, and regeneration. This will provide an overview of the current research on the rapid development of MSC-based therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available