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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Mutant p53 mediates survival of breast cancer cells
L. Y. Lim et al.
BRITISH JOURNAL OF CANCER (2009)
Altered Subcellular Localization of Tumor-Specific Cyclin E Isoforms Affects Cyclin-Dependent Kinase 2 Complex Formation and Proteasomal Regulation
Nikki A. Delk et al.
CANCER RESEARCH (2009)
Mutant p53 Drives Invasion by Promoting Integrin Recycling
Patricia A. J. Muller et al.
CELL (2009)
Low molecular weight cyclin E is specific in breast cancer and is associated with mechanisms of tumor progression
Hannah Wingate et al.
CELL CYCLE (2009)
FoxM1, a critical regulator of oxidative stress during oncogenesis
Hyun Jung Park et al.
EMBO JOURNAL (2009)
Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
Peixin Dong et al.
MOLECULAR CANCER (2009)
The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis
Giulia Fontemaggi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
JNK regulates APP cleavage and degradation in a model of Alzheimer's disease
Alessio Colombo et al.
NEUROBIOLOGY OF DISEASE (2009)
Cell cycle, CDKs and cancer: a changing paradigm
Marcos Malumbres et al.
NATURE REVIEWS CANCER (2009)
Redox imbalance in Parkinson's disease
Shankar J. Chinta et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2008)
The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia
Ian R. A. Mackenzie et al.
CURRENT OPINION IN NEUROLOGY (2008)
Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE, in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease
Giovanna Cenini et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Edor Kabashi et al.
NATURE GENETICS (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
Hui-Ming Gao et al.
TRENDS IN IMMUNOLOGY (2008)
Multiple pathways regulated by the tumor suppressor PP2A in transformation
Jukka Westermarck et al.
TRENDS IN MOLECULAR MEDICINE (2008)
Novel Mutations in TARDBP(TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis
Nicola J. Rutherford et al.
PLOS GENETICS (2008)
Conformationally altered p53: a novel Alzheimer's disease marker?
C. Lanni et al.
MOLECULAR PSYCHIATRY (2008)
Cyclin E low molecular weight isoforms occur commonly in early-onset gastric cancer and independently predict survival
A. N. A. Milne et al.
JOURNAL OF CLINICAL PATHOLOGY (2008)
Risk of malignancy in patients with schizophrenia or bipolar disorder - Nested case-control study
Julia Hippisley-Cox et al.
ARCHIVES OF GENERAL PSYCHIATRY (2007)
Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma
Ben Davidson et al.
CANCER (2007)
PIN1, the cell cycle and cancer
Elizabeth S. Yeh et al.
NATURE REVIEWS CANCER (2007)
P53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
Hoseok Song et al.
NATURE CELL BIOLOGY (2007)
Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons
Haripriya Vittal Rao et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Neuronal cell cycle re-entry mediates Alzheimer disease-type changes
Andrew McShea et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)
The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease
Guenter U. Hoeglinger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
P53 protein, interferon-γ, and NF-κB levels are elevated in the parkinsonian brain
Makio Mogi et al.
NEUROSCIENCE LETTERS (2007)
Mutant p53 in MDA-MB-231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D
L. Hui et al.
ONCOGENE (2006)
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production
L Pastorino et al.
NATURE (2006)
Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery
EBE Becker et al.
NEURON (2006)
Prolyl-isomerase Pin1 accumulates in Lewy bodies of Parkinson disease and facilitates formation of α-synuclein inclusions
A Ryo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model
V Khurana et al.
CURRENT BIOLOGY (2006)
Tumor-specific hyperactive low-molecular-weight cyclin E isoforms detection and characterization in non-metastatic colorectal tumors
I Corin et al.
CANCER BIOLOGY & THERAPY (2006)
The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability
ES Yeh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53
A Zalcenstein et al.
ONCOGENE (2006)
Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression
G Bossi et al.
ONCOGENE (2006)
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
MW Landis et al.
CANCER CELL (2006)
Cancer-associated PP2A Aα subunits induce functional haploinsufficiency and tumorigenicity
W Chen et al.
CANCER RESEARCH (2005)
Evaluation of the molecular mechanisms involvedin the gain of function of a Li-Fraumeni TP53 mutation
S Capponcelli et al.
HUMAN MUTATION (2005)
α-Synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells
XMM Peng et al.
JOURNAL OF CELL SCIENCE (2005)
Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease
H Tanimukai et al.
AMERICAN JOURNAL OF PATHOLOGY (2005)
The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27
H Wingate et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease
Y Ohyagi et al.
FASEB JOURNAL (2005)
Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p2l, p27, and antiestrogens in breast cancer
S Akli et al.
CANCER RESEARCH (2004)
Altered expression levels of the protein phosphatase 2A ABαC enzyme are associated with Alzheimer disease pathology
E Sontag et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)
Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant β-catenin expression
M Nakashima et al.
JOURNAL OF PATHOLOGY (2004)
Intracellular Aβ42 activates p53 promoter:: a pathway to neurodegeneration in Alzheimer's disease
Y Ohyagi et al.
FASEB JOURNAL (2004)
Modulation of gene expression by tumor-derived p53 mutants
MJ Scian et al.
CANCER RESEARCH (2004)
Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes
MJ Scian et al.
ONCOGENE (2004)
PIN1 overexpression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma
R Pang et al.
ONCOGENE (2004)
Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells
NE Willmarth et al.
BREAST CANCER RESEARCH (2004)
Prevalent overexpression of prolyl isomerase Pin1 in human cancers
L Bao et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
YC Liou et al.
NATURE (2003)
Parkin is a component of an SCF-like ubipuitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
JF Staropoli et al.
NEURON (2003)
Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain
XD Wang et al.
ONCOGENE (2003)
Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation
T Uchida et al.
CHEMISTRY & BIOLOGY (2003)
Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis
JD Moore et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Overexpression of cyclin E protein is closely related to the mutator phenotype of colorectal carcinoma
T Sutter et al.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2002)
Substrate-based design of reversible Pin1 inhibitors
YX Zhang et al.
BIOCHEMISTRY (2002)
PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells
A Ryo et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Complex functions of mutant p53 alleles from human prostate cancer
XB Shi et al.
PROSTATE (2002)
Kainic acid-induced apoptosis in cerebellar granule neurons:: an attempt at cell cycle re-entry
E Verdaguer et al.
NEUROREPORT (2002)
To cycle or not to cycle: A critical decision in cancer
M Malumbres et al.
NATURE REVIEWS CANCER (2001)
Reduced expression of the Aα subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aα and Aβ subunit genes
S Colella et al.
INTERNATIONAL JOURNAL OF CANCER (2001)
Glutamate release promotes growth of malignant gliomas
T Takano et al.
NATURE MEDICINE (2001)
Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms
DC Porter et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1
GM Wulf et al.
EMBO JOURNAL (2001)
Specific protection against breast cancers by cyclin D1 ablation
QY Yu et al.
NATURE (2001)
Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells
JY Kim et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2001)
Prognostic implications of p27 and cyclin E protein contents in malignant lymphomas
M Erlanson et al.
LEUKEMIA & LYMPHOMA (2001)
Regulation of G1 cyclin dependent kinases in the mammalian cell cycle
SV Ekholm et al.
CURRENT OPINION IN CELL BIOLOGY (2000)
Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease
NA Tatton
EXPERIMENTAL NEUROLOGY (2000)
A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model
KL Murphy et al.
FASEB JOURNAL (2000)
Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL
AJ Anderson et al.
NEUROBIOLOGY OF AGING (2000)
Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study
PF Behrens et al.
JOURNAL OF NEURO-ONCOLOGY (2000)
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