Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 77, Issue 14, Pages 2659-2680Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03428-3
Keywords
Age-related diseases; Cell death; Cell survival; Redox system; Glioma; Neurotoxicity
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Funding
- Original Technology Research Program for Brain Science of the National Research Foundation of Korea (NRF) - Korean government (MSIT) [2018M3C7A1021848]
- National Research Foundation of Korea [2018M3C7A1021848] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The progression of cancers and neurodegenerative disorders is largely defined by a set of molecular determinants that are either complementarily deregulated, or share remarkably overlapping functional pathways. A large number of such molecules have been demonstrated to be involved in the progression of both diseases. In this review, we particularly discuss our current knowledge on p53, cyclin D, cyclin E, cyclin F, Pin1 and protein phosphatase 2A, and their implications in the shared or distinct pathways that lead to cancers or neurodegenerative diseases. In addition, we focus on the inter-dependent regulation of brain cancers and neurodegeneration, mediated by intercellular communication between tumor and neuronal cells in the brain through the extracellular microenvironment. Finally, we shed light on the therapeutic perspectives for the treatment of both cancer and neurodegenerative disorders.
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