Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 77, Issue 12, Pages 2257-2273Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03401-0
Keywords
Transplantation; Angiogenesis; Vasculogenesis; Endothelial cells; Nephrons
Categories
Funding
- RECellularizing ORgan Donors for KIDney bioengineering (RECORD KID, Dutch Kidney Foundation) [15RN02]
- Wiyadharma fellowship (Bontius Stichting, LUMC)
Ask authors/readers for more resources
Kidney organoids can be generated from human pluripotent stem cells (PSCs) using protocols that resemble the embryonic development of the kidney. The renal structures thus generated offer great potential for disease modeling, drug screening, and possibly future therapeutic application. At the same time, use of these PSC-derived organoids is hampered by lack of maturation and off-target differentiation. Here, we review the main protocols for the generation of kidney organoids from human-induced PSCs, discussing their advantages and limitations. In particular, we will focus on the vascularization of the kidney organoids, which appears to be one of the critical factors to achieve maturation and functionality of the organoids.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available