Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 17, Issue 2, Pages 113-122Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/s41423-019-0359-1
Keywords
human; T cells; tissue-resident; memory; immunity
Categories
Funding
- Oxford-Celgene Postdoctoral Fellowship
- NHMRC [GNT 1160963]
- NIHR [WT10966MA]
- Sylvia and Charles Viertel Charitable Foundation
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Tissue-resident memory T (T-RM) cells are increasingly associated with the outcomes of health and disease. T-RM cells can mediate local immune protection against infections and cancer, which has led to interest in T-RM cells as targets for vaccination and immunotherapies. However, these cells have also been implicated in mediating detrimental pro-inflammatory responses in autoimmune skin diseases such as psoriasis, alopecia areata, and vitiligo. Here, we summarize the biology of T-RM cells established in animal models and in translational human studies. We review the beneficial effects of T-RM cells in mediating protective responses against infection and cancer and the adverse role of T-RM cells in driving pathology in autoimmunity. A further understanding of the breadth and mechanisms of T-RM cell activity is essential for the safe design of strategies that manipulate T-RM cells, such that protective responses can be enhanced without unwanted tissue damage, and pathogenic T-RM cells can be eliminated without losing local immunity.
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