Journal
CELL HOST & MICROBE
Volume 27, Issue 3, Pages 389-+Publisher
CELL PRESS
DOI: 10.1016/j.chom.2020.01.006
Keywords
-
Categories
Funding
- Ingredion Incorporated
- Campus Alberta Innovation Program
- Canada Foundation for Innovation
- Canadian Institutes of Health Research
- Joint Programming Initiative for a Healthy Life (JPI-HDHL)
Ask authors/readers for more resources
Dietary fibers (DFs) impact the gut microbiome in ways often considered beneficial. However, it is unknown if precise and predictable manipulations of the gut microbiota, and especially its metabolic activity, can be achieved through DFs with discrete chemical structures. Using a dose-response trial with three type-IV resistant starches (RS4s) in healthy humans, we found that crystalline and phosphate cross-linked starch structures induce divergent and highly specific effects on microbiome composition that are linked to directed shifts in the output of either propionate or butyrate. The dominant RS4-induced effects were remarkably consistent within treatment groups, dose-dependent plateauing at 35 g/day, and can be explained by substrate-specific binding and utilization of the RS4s by bacterial taxa with different pathways for starch metabolism. Overall, these findings support the potential of using discrete DF structures to achieve targeted manipulations of the gut microbiome and its metabolic functions relevant to health.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available