4.7 Editorial Material

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

Journal

CELL HOST & MICROBE
Volume 27, Issue 3, Pages 325-328

Publisher

CELL PRESS
DOI: 10.1016/j.chom.2020.02.001

Keywords

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Funding

  1. National Key Plan for Scientific Research and Development of China [2016YFD0500301, 2016YFC1200200]
  2. CAMS Initiative for Innovative Medicine (CAMS-I2M)
  3. National Natural Science Foundation of China [U1603126]
  4. Central Public-Interest Scientific Institution Basal Research Fund [2016ZX310195, 2017PT31026, 2018PT31016]
  5. NIH (United States) [R01AI069120]
  6. CAMS Initiative for Innovative Medicine [2016-I2M-1-005]

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An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV.

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