Journal
CELL CALCIUM
Volume 84, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2019.102103
Keywords
Phospholipids; Anion channels; Ion channel gating; Calcium; Ion channel regulation
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Funding
- CONACYT, Mexico [FC 2016-01-1955, 219949]
- National Institutes of Health [EY0114852, AR067786, GM132598]
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Recently there has been a flurry of interest in the regulation of the homo-dimeric calcium-activated chloride channel ANO1 (also known as TMEM16A) by phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P-2). These recent studies show that upon Ca2+ binding, PI(4,5)P-2 cooperates to maintain the conductive state of ANO1. PI(4,5)P-2 does so by binding to sites or modules on the protein's cytosolic side. These findings add a new function to the PI (4,5)P-2 repertoire and a new dimension to ANO1 gating.
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