Journal
CELL
Volume 180, Issue 4, Pages 780-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2020.01.028
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Funding
- program Investissements d'avenir'' [ANR-10-IAIHU-06]
- ERC starter grant NeuroRemod'' (EU Horizon 2020 research program) [758817]
- Paris Emergences'' program
- Kavli Neural Systems Institute
- Center for Physics and Biology at the Rockefeller University
- Region Ile-de-France DIM Math'Innov
- ANR as part of the second Investissements d'Avenir program LIGHT4DEAF [ANR-15-RHUS-0001]
- LabEx LIFESENSES [ANR-10-LABX-65]
- LHW-Stiftung
- Prix Emergence of the Fondation pour l'Audition
- Marie Sklodowska-Curie grant [845685]
- Marie Curie Actions (MSCA) [845685] Funding Source: Marie Curie Actions (MSCA)
- European Research Council (ERC) [758817] Funding Source: European Research Council (ERC)
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The cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying variations of the vascular organization across individuals, brain regions, or disease models is challenging. We used immunolabeling and tissue clearing to image the vascular network of adult mouse brains and developed a pipeline to segment terabyte-sized multi-channel images from light sheet microscopy, enabling the construction, analysis, and visualization of vascular graphs composed of over 100 million vessel segments. We generated datasets from over 20 mouse brains, with labeled arteries, veins, and capillaries according to their anatomical regions. We characterized the organization of the vascular network across brain regions, highlighting local adaptations and functional correlates. We propose a classification of cortical regions based on the vascular topology. Finally, we analysed brain-wide rearrangements of the vasculature in animal models of congenital deafness and ischemic stroke, revealing that vascular plasticity and remodeling adopt diverging rules in different models.
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