Journal
CELL
Volume 180, Issue 5, Pages 956-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2020.01.033
Keywords
-
Categories
Funding
- Canadian Institutes of Health Research
- pilot grant from the Groupe d'Etude des Proteines Membranaires (GEPROM)
- Fonds de Recherche du Quebec-Sante
- Fondation pour la Recherche Medicale (Equipe FRM 2015)
- Agence Nationale pour la Recherche [ANR15-CE16-0012-01]
- Agence Nationale pour la Recherche (LABEX ICST)
- Canadian Institutes of Health Research [MOP-136903]
- NHMRC [APP1122104]
- Louise and Alan Edwards Foundation
- Natural Sciences and Engineering Research Council of Canada (NSERC) [PGSD2-517068-2018]
- Ontario Thoracic Society
- Canada Foundation for Innovation John R. Evans Leaders Fund [31979]
Ask authors/readers for more resources
Mechanotransduction, the conversion of mechanical stimuli into electrical signals, is a fundamental process underlying essential physiological functions such as touch and pain sensing, hearing, and proprioception. Although the mechanisms for some of these functions have been identified, the molecules essential to the sense of pain have remained elusive. Here we report identification of TACAN (Tmem120A), an ion channel involved in sensing mechanical pain. TACAN is expressed in a subset of nociceptors, and its heterologous expression increases mechanically evoked currents in cell lines. Purification and reconstitution of TACAN in synthetic lipids generates a functional ion channel. Finally, a nociceptor-specific inducible knockout of TACAN decreases the mechanosensitivity of nociceptors and reduces behavioral responses to painful mechanical stimuli but not to thermal or touch stimuli. We propose that TACAN is an ion channel that contributes to sensing mechanical pain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available