Journal
CELL
Volume 180, Issue 1, Pages 20-22Publisher
CELL PRESS
DOI: 10.1016/j.cell.2019.12.020
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Funding
- National Institutes of Health [R01 HL132266, R01 HL125821]
- Celgene IDEAL Consortium
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Idiopathic pulmonary fibrosis is a fatal disease involving destruction of the lung alveolar structure. In this issue of Cell, Wu et al. (2020) show that impaired alveolar (AT2) stem cells produce mechanical tension that leads to spatially regulated fibrosis, initiating a new chapter in understanding what underlies the periphery to center progression of this lung disease.
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