Journal
CARDIOLOGY CLINICS
Volume 38, Issue 1, Pages 129-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccl.2019.09.008
Keywords
Calcific aortic stenosis; Sex differences; Pathophysiology; Diagnosis; Outcome; Transcatheter aortic valve implantation; Surgical aortic valve replacement
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For years, calcific aortic stenosis (AS) was considered to be similar in men and women, and the underrepresentation of women in research studies prevented any alternate conclusions. With new sex-specific studies and data, the landscape of AS is evolving and recently important sex-disparities were revealed. These sex-specific discrepancies are of utmost importance to stratify and personalize treatment according to sex. It is important and urgent to elucidate the sex-related differences and similarities in the pathophysiology of AS to develop and validate sex- specific approaches for the management and pharmacologic treatment of AS, and to improve clinical outcomes for both sexes.
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