Journal
CARBOHYDRATE POLYMERS
Volume 237, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116119
Keywords
Photodynamic therapy; Fluorinated-functionalized hyaluronic acid; Hypoxia; Oxygen carrier
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Funding
- National Key Research and Development Plan [2018YFC1106100]
- National Natural Science Foundation of China [81770960, 81600766, 21574039, 51173044]
- Science and Technology Commission of Shanghai [17DZ2260100]
- Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20152228]
- Ph.D. Innovation Fund of Shanghai Jiao Tong University School of Medicine [BXJ201933, BXJ201929]
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Photodynamic therapy (PDT) is a method for killing cancer cells by employing reactive singlet oxygen (O-1(2)). However, the inherent hypoxia and oxygen consumption in tumors during PDT lead to a deficient oxygen supply, which in turn hinder the photodynamic efficacy. To overcome this issue, fluorinated-functionalized polysaccharide-based nanocomplexes were prepared by anchoring perfluorocarbons (PFCs) and pyropheophorbide a (Ppa) onto the polymer chains of hyaluronic acid (HA) to deliver O-2 in hypoxia area. These amphiphilic conjugates can self-assemble into micelles and its application in PDT is evaluated. Due to the high oxygen affinity of perfluorocarbon segments, and the tumor-targeting nature of HA, the photodynamic effect of the oxygen selfcarrying micelles is remarkably enhanced, which is confirmed by increased generation of O-1(2) and elevated phototoxicity in vitro and in vivo. These results emphasize the promising potential of polysaccharide-based nanocomplexes for enhanced PDT of Ocular Choroidal Melanoma.
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