Journal
CARBOHYDRATE POLYMERS
Volume 232, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115786
Keywords
OH-CATH30; PVA; Wound healing; Nanofibers; Nanoparticles
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Funding
- National Natural Science Foundation of China [NSFC81673576, 31600775]
- Shandong Provincial Natural Science Foundation of China [ZR2016HM76]
- Science and Technology Department of Yunnan Province [2019ZF003]
- Youth Innovative Team Development Plan of Universities in Shandong Province [2019KJM003]
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Novel nanomaterials have been developed for antimicrobial and wound healing applications. Here, we report the preparation of a polyvinyl alcohol/chitosan (PVA/CS) nanofiber with carboxymethyl chitosan nanoparticles (CMCS-OH30 NPs) encapsulating the antibacterial peptide OH-CATH30 (OH-30). The PVA/CS nanofibers containing OH-30 NPs (NP-30-NFs) obtained via electrospinning could achieve a secondary embedded OH-30. The effect of NP-30-NFs on the release of OH-30 was investigated through high-performance liquid chromatography. The antibacterial activities of NP-30-NFs against Escherichia coli and Staphylococcus aureus were studied by bacterial plate counting. NP-30-NFs containing different concentrations of NPs were applied to mouse skin wounds to determine their effectiveness in promoting wound healing. Results showed that NP-30-NFs exhibited antibacterial properties and promoted skin wound healing.
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