Journal
CARBOHYDRATE POLYMERS
Volume 229, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115477
Keywords
Anemarrhena asphodeloides Bunge; Polysaccharide; Fructan; Neuroprotection; Immunomodulation
Categories
Funding
- National Key Research and Development Program of China [2018YFA0507204]
- National Natural Science Foundation of China [U1703107, U1801288]
- Fundamental Research Funds for the Central Universities (Nankai University) [63191142, 63191731]
- Hundred Young Academic Leaders Program of Nankai University
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR2018-B02]
- Natural Science Foundation of Tianjin [19JCYBJC28100, 16JCQNJC13500]
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A novel polysaccharide, AAP70-1, was isolated from Anemarrhena asphodeloides for the first time. The primary structural analysis revealed that AAP70-1 was composed of glucose and fructose, had an absolute molecular weight of 2720 Da, and contained a (2 -> 6)-linked beta-D-fructofuranose (Fruf) backbone and a (2 -> 1,6)-linked beta-D-Fruf side chain with an internal alpha-D-glucopyranose (Glcp) in the form of a neokestose. To explore the potential factors responsible for the medicinally relevant bioactivities of A. asphodeloides, a biological assay was performed. Using flow cytometry analysis, AAP70-1 was experimentally shown to have neuroprotective effects, and it can prevent and ameliorate neurological damage via reducing apoptosis. The immunomodulation assay further revealed that AAP70-1 can significantly improve immune function by promoting phagocytic capacity and the secretion of cytokines (IL-6, IL-1 beta and TNF-alpha) in RAW264.7 cells. These results suggest that AAP70-1 has potential as a therapeutic agent for central nervous system diseases or as an immunomodulatory agent.
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