Journal
CANCER CELL
Volume 37, Issue 1, Pages 1-2Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2019.12.008
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Therapeutic resistance is a major challenge in cancer treatment. In this issue of Cancer Cell, Kurppa et al. demonstrated that a senescence-like state enables lung cancer cells to survive dual inhibition of EGFR and MEK. This was mediated by the YAP/TEAD pathway, which drives epigenomic reprogramming and EMT to counteract apoptosis.
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