Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 168, Issue 3, Pages 361-365Publisher
SPRINGER
DOI: 10.1007/s10517-020-04709-9
Keywords
photosensitizer; lipophthalocyan; specific activity; photodynamic therapy; transplantable mouse tumors
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We studied specific antitumor activity of a liposomal drug based on tetra-3-phenylthiophthalocyanine aluminum hydroxide (lipophthalocyan) intended for photodynamic therapy. The optimal dose and protocol for photodynamic therapy with lipophthalocyan were chosen in experiments on mice: single intravenous dose of 6 mg/kg with a 5-h interval between administration and laser exposure and irradiation energy density of 400 J/cm(2). A wide spectrum antitumor activity of lipophthalocyan was demonstrated in vivo for various transplantable mouse tumors (Lewis lung epidermoid carcinoma, S37 sarcoma, and colon adenocarcinoma AKATOL). The results show the possibility of using lipophthalocyan for photodynamic therapy of tumors of surface localization (skin and mucosa tumors).
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