4.5 Article

Increased level of NEAT1 long non-coding RNA is detectable in peripheral blood cells of patients with Parkinson's disease

Journal

BRAIN RESEARCH
Volume 1730, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.brainres.2020.146672

Keywords

Long non-coding RNA; Parkinson's disease; NEAT1; Neurodegeneration

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Funding

  1. Hungarian Brain Research Program [KTIA_13_NAP-A-II/17]
  2. Economic Development and Innovation Operational Programme [GINOP-2.3.2-15-2016-00034]

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Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder that poses serious burden to individuals and society as well. Although a number of PD associated genetic factors haNie been identified, the molecular mechanism of the disease so far has not been completely elucidated. Involvement of long non-coding RNAs (lncRNAs) in the pathology of neurodegenerative disorders is attracting increased interest because of the diverse mechanisms lncRNAs affect gene expression and cellular homeostasis at different levels. We aimed to test the feasibility of detecting alterations in IncRNA levels in easily accessible samples of PD patients by routine laboratory technique. By narrowing the number of selected lncRNAs implicated in neurodegeneration and increasing the number of PD samples included, we found one out of 41 lncRNAs readily detectable in increased level in peripheral blood of PD patients. We detected NEAT1 to be significantly up-regulated in PD patients in multiple comparisons. NEAT1 is the core element of nuclear paraspeckles and it plays role in regulation of transcription, mRNA and miRNA levels, mitochondrial and cellular homeostasis. Our finding is in accord with recent data demonstrating changes in the level of NEAT1 in neurons of PD patients and in several models of the disease. However, to our knowledge this is the first study to report NEAT1 up-regulation in blood of PD patients. Identification of altered expression of this IncRNA in the periphery might help to a better understanding of the mechanisms underlying PD, and can contribute to the identification of new therapeutic targets and disease markers.

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