Journal
BRAIN BEHAVIOR AND IMMUNITY
Volume 87, Issue -, Pages 243-255Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2019.12.007
Keywords
Ca2+ signaling; In vivo; Microglia; Peripheral inflammation
Categories
Funding
- VolkswagenStiftung [90233]
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Peripheral inflammation is known to trigger a mirror inflammatory response in the brain, involving brain's innate immune cells - microglia. However, the functional phenotypes, which these cells adopt in the course of peripheral inflammation, remain obscure. In vivo two-photon imaging of microglial Ca2+ signaling as well as process motility reveals two distinct functional states of cortical microglia during a lipopolysaccharide-induced peripheral inflammation: an early sensor state characterized by dramatically increased intracellular Ca2+ signaling but ramified morphology and a later effector state characterized by slow normalization of intracellular Ca2+ signaling but hypertrophic morphology, substantial IL-1 beta production in a subset of cells as well as increased velocity of directed process extension and loss of coordination between individual processes. Thus, lipopolysaccharide-induced microglial Ca2+ signaling might represent the central element connecting receptive and executive functions of microglia.
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