Journal
BIOMATERIALS
Volume 223, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2019.119479
Keywords
Anti-biofilm; Mesoporous polydopamine nanoparticles; Titanium implants; Photothermal therapy; Photodynamic therapy
Funding
- State Key Project of Research and Development [2016YFC1100300, 2017YFB0702603]
- National Natural Science Foundation of China [51825302, 21734002, 51673032]
- Fundamental Research Funds for the Central Universities [2018CDYJSY0055, 2019CDXYSG0004, 2018CDXYSW0023]
- Chongqing Research Program of Technological Innovation and Application Demonstration [cstc2018jscx-msybX0299]
- Innovation Team in University of Chongqing Municipal Government [CXTDX201601002]
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Biofilm formation is a main challenge in treatment of bone-implant-associated infections, resulting in tolerance to immune system and antibiotics. However, smart non-surgical or non-invasive treatment methods of combating established biofilm on an implant have been less reported. Herein, a therapeutic system consisting of mesoporous polydopamine nanoparticles (MPDA) to combat biofilm is reported for the first time. We develop a synergistic photothermal/photodynamic therapy (PTT/PDT) strategy aiming for biofilms eradication on titanium (Ti) implant, which is integrated with MPDA loading with photosensitizer Indocyanine Green (ICG) by pi-pi stacking. Specifically, MPDA is functionalized with RGD peptide to endow the modified Ti sample (Ti-M/I/RGD) with good cytocompatibility. More importantly, Ti-M/I/RGD implant remarkably kills Staphylococcus aureus (S. aureus) biofilm with an efficiency of 95.4% in vivo upon near infrared (NIR). After biofilm eradication, implant still displays great performance regarding osteogenesis and osseointegration. Overall, this study provides a PTT/PDT strtategy for the development of antibacterial Ti implants for potential orthpediac application.
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