Journal
BIOMATERIALS
Volume 230, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2019.119598
Keywords
Supramolecular hydrogel; Isoguansine-borate-guanosine; Drug delivery; Oral cancer therapy
Funding
- National Natural Science Foundation of China [81922020, 81970950, 81700988, 81621062]
- Sichuan university [20826041A4403]
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Supramolecular hydrogel delivery systems have attracted widely attention owing to incorporating various therapeutic agents in carriers to decrease unpredictable toxicities, improve curative efficacy, and protect drug bioactivity. Nonetheless, the dual-functional supramolecular hydrogel integrating localized delivery and antineoplastic activities in one system have rarely observed. In this study, we successfully developed a novel supramolecular hydrogel, isoguanosine-borate-guanosine (isoGBG), with reversibly and dynamic borate ester bonds formed via boric acids and diols derived from nature products guanosine and isoguanosine in one pot by following a simple procedure. Both in vivo and in vitro results demonstrated that the isoGBG hydrogel not only displays excellent stability, self-healing properties and biocompatibility, but also has highly anti-tumor activities through inducing tumor cell apoptosis and excellent inhibition effect of tumor recurrence. These findings suggested that isoGBG hydrogel can serve as a dual-function hydrogel system integrating drug carrier and anti-cancer compound in one system, which provided a promising strategy for the design of functional supramolecular hydrogel in the local management of cancer in the future.
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