Journal
BIOMATERIALS
Volume 232, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2019.119684
Keywords
Semiconducting polymer; Amphiphile; Second near-infrared window; Photoacoustic imaging; Photothermal therapy
Funding
- National Natural Science Foundation of China [31570979]
- General Research Fund grant from the Research Grants Council of Hong Kong [14220716]
- Health and Medical Research Fund
- Food and Health Bureau
- Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong
- Shenzhen Science and Technology Innovation Commission Project [JCYJ20170307165611557]
- National Natural Science Foundation of China (NSFC) [81627805, 61805102]
- Research Grants Council of the Hong Kong Special Administrative Region [21205016, 11215817, 11101618]
- Shenzhen Basic Research Project [JCYJ20160329150236426, JCYJ20170413140519030]
- City University of Hong Kong [9667179]
- Government of the Hong Kong Special Administrative Region [04152836]
Ask authors/readers for more resources
Development of near-infrared-II (NIR-II) light responsive nano-agents with high photothermal stability, high photothermal conversion efficiency (PCE), and excellent biocompatibility for photoacoustic (PA) imaging-guided photothermal therapy (PIT) is of tremendous significance. In spite of the superiority of organic semiconducting polymer nanoparticles (OSPNs) in PA imaging-guided PIT, the limited absorption in the first NIR (NIR-I) window and metastable nanostructure of OSPNs resulting from commonly used preparation methods based on nanoprecipitation or reprecipitation compromise their in vivo phototheranostic performance. Herein we design and synthesize a novel NIR-II absorbing organic semiconducting polymer amphiphile (OSPA) to enhance the structural stability of OSPNs. With prominent optical properties, low toxicity, and a suitable size, OSPA not only efficiently labels and kills cancer cells under NIR-II irradiation but also accumulates at the tumor of living mice upon intravenous injection, allowing efficient NIR-II light-triggered phototheranostics toward tumor. The developed OSPA has promising potential for fabricating multifunctional nanoplatforms to enable multimodal theranostics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available