Journal
BIOESSAYS
Volume 42, Issue 5, Pages -Publisher
WILEY
DOI: 10.1002/bies.201900158
Keywords
circadian clocks; endocrine rhythms; peripheral clocks; SCN; transcriptional rhythms
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Funding
- German Research Foundation [GRK-1957, HO353-7/1]
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In mammals, a network of cellular circadian clocks organizes physiology and behavior along the 24-h day cycle. The traditional hierarchical model of circadian clock organization with a central pacemaker and peripheral slave oscillators has recently been challenged by studies combining tissue-specific mouse mutants with transcriptome analyses. First, a surprisingly small number of tissue rhythms are lost when only local clocks are ablated and, second, transcriptional circadian rhythms appear to be regulated by a complex mix of local and systemic factors. As reviewed here, these findings suggest a more integrated model of clock network interaction with the central pacemaker as the main source of behavioral and systemic-physiological rhythms and peripheral clocks controlling some local rhythms while at the same time acting as gatekeepers that temporally adjust cellular responses to external stimuli.
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