Journal
BIOCONJUGATE CHEMISTRY
Volume 31, Issue 2, Pages 404-415Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.9b00851
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [31622025, 51873228, 31671024, 81671695, 81725008]
- CAS President's International Fellowship Initiative Program [2019PB0023]
- Shanghai Municipal Health Commission [2019LJ21]
- Science and Technology Commission of Shanghai Municipality [19441903200]
- Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences [2019-027]
Ask authors/readers for more resources
The importance of the immune system in cancer therapy has been reaffirmed by the success of the immune checkpoint blockade. The complex tumor microenvironment and its interaction with the immune system, however, remain mysteries. Molecular imaging may shed light on fundamental aspects of the immune response to elucidate the mechanism of cancer immunotherapy. In this review, we discuss various imaging approaches that offer in-depth insight into the tumor microenvironment, checkpoint blockade therapy, and T cell-mediated antitumor immune responses. Recent advances in the molecular imaging modalities, including magnetic resonance imaging (MRI), positron electron tomography (PET), and optical imaging (e.g., fluorescence and intravital imaging) for in situ tracking of the immune response, are discussed. It is envisaged that the integration of imaging with immunotherapy may broaden our understanding to predict a particular antitumor immune response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available