Journal
BIOCONJUGATE CHEMISTRY
Volume 31, Issue 4, Pages 967-989Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.0c00029
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Funding
- Terry Fox Research Institute
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Princess Margaret Cancer Foundation
- McLaughlin Centre
- Canada Research Chairs Program
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Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are activated by deep-tissue-penetrating low frequency ultrasound. Despite growing research in recent years, the field has yet to clearly elucidate broadly applicable mechanisms by which acoustic cavitation triggers sonosensitizer therapeutic activity, creating difficulties in achieving substantial and translatable therapeutic efficacy. In this review, we will critically analyze the proposed mechanisms underlying SDT and overview how nanomedicines can complement and extend these mechanisms to deliver more efficacious SDT. In doing so, we aim to highlight potential avenues toward viable implementation of SDT as a cancer therapy.
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