Journal
BIOCONJUGATE CHEMISTRY
Volume 31, Issue 3, Pages 646-655Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.9b00801
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Funding
- National Natural Science Foundation of China [51873023, 51973214]
- Talent Development Fund of Jilin Province
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A new type of fluorine-doped carbon dots (FCDs) with the nucleus-targeting capability was prepared and utilized as a promising candidate for drug and dye delivery. Doxorubicin (DOX) and boron dipyrromethene (BODIPY) was used as a model drug and dye, respectively, to construct FCD-DOX and FCD-BODIPY nanocomposites via coassembly with FCDs. The results demonstrate that FCDs can remarkably increase the cellular uptake and delivery of DOX and BODIPY. This work developed a convenient strategy to construct CDs-based nanohybrids for nucleus-targeted bioimaging and cancer treatment.
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