Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1864, Issue 3, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbagen.2019.129475
Keywords
Neutron scattering; Water diffusion in brain and cancer cells; Extremophile; Adaptation through molecular dynamics; Deep sea microbes; Stress response
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Funding
- French National Research Agency [ANR-15-IDEX-02]
- FILL2030, a European Union project within the European Commission's Horizon 2020 Reasearch and Innovation program [731096]
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Experiments to characterize intracellular molecular dynamics in vivo are discussed following a description of the incoherent neutron scattering method. Work reviewed includes water diffusion in bacteria, archaea, red blood cells, brain cells and cancer cells, and the role of proteome molecular dynamics in adaptation to physiological temperature and pressure, and in response to low salt stress in an extremophile. A brief discussion of the potential links between neutron scattering results and MD simulations on in-cell dynamics concludes the review.
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