Journal
BIOCHEMICAL ENGINEERING JOURNAL
Volume 153, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bej.2019.107397
Keywords
Fumaric acid; Strain improvement; Process development; Waste resources
Funding
- National Key Research and Development Program of China [2018YFA0902200]
- Jiangsu Province Natural Science Foundation for Youths [BK20170993, BK20170997]
- Jiangsu Synergetic Innovation Center for Advanced BioManufacture
- National Natural Science Foundation of China [21978130, 21706125, 21727818]
- Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals Foundation [JSBEM201908]
- Project of State Key Laboratory of Materials-Oriented Chemical Engineering [ZK201601]
Ask authors/readers for more resources
Fumaric acid is an industrially important platform chemical, which has been widely used in food, chemicals, agriculture and pharmaceutical industries. Due to the rising price of raw materials in traditional petrochemical method and demand for sustainable development, fermentative fumaric acid production has attracted great attention. In this context, various strains with enhanced fumaric acid production or elimination of by-products were developed through mutagenesis or metabolic engineering. In addition, renewable organic wastes together with the fermentation process optimization have also been widely investigated. Accordingly, this review will comprehensively summarize the achievements of fermentative fumaric acid production in recent years and major obstacles occurring in industrialization to provide insights and perspective for future microbial fermentation of fumaric acid.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
