Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 531, Issue 1, Pages 18-24Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2020.02.114
Keywords
G-quadruplex; Fluorescent probe; Cell imaging
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Funding
- National Natural Science Foundation of China [21672268]
- Outstanding Youth Programme of Special Support Plan in Guangdong Province [2015TQ01R342]
- Guangdong Provincial Key Laboratory of Construction Foundation [2017B030314030]
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G-quadruplexes are non-canonical nucleic acid structures formed by guanine-rich DNA or RNA sequences. In recent decades, an increasing number of evidences have suggested that G-quadruplexes are associated with a wide range of biological events. Therefore, to further study the function and distribution of G-quadruplexes, developing new probes is an essential part of G-quadruplexes research. In the review, several examples of chemical fluorescent probes for G-quadruplexes developed in recent years are highlighted. These probes are promising tools for future G-quadruplex studies, which display outstanding selectivity and capability of cell imaging. (C) 2020 Elsevier Inc. All rights reserved.
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